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Article

Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease.

Journal of virology - 1 Dec 2007

Kang Hyojeung, Bhardwaj Kanchan, Li Yi, Palaninathan Satheesh, Sacchettini James, Guarino Linda, Leibowitz Julian L, Kao C Cheng

Abstract excerpt

The goal of this project was to better define the relationship between the endoribonuclease activity of murine hepatitis virus (MHV) Nsp15 (mNsp15) and its role in virus infection. Molecular modeling demonstrated that the catalytic residues of mNsp15 are superimposable with its severe acute respiratory syndrome coronavirus ortholog. Alanine substitutions at three key residues in the mNsp15 catalytic pocket (H262,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17898055
DOI: 10.1128/JVI.00547-07
PMCID: PMC2168834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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