A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses.

doi:10.1371/journal.ppat.1012571

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses.

PLoS pathogens - 1 Feb 2025

Van Loy Benjamin, Pujol Eugènia, Kamata Kenichi, Lee Xiao Yin, Bakirtzoglou Nikolai, Van Berwaer Ria, Vandeput Julie, Mestdagh Cato, Persoons Leentje, De Wijngaert Brent, Goovaerts Quinten, Noppen Sam, Jacquemyn Maarten, Ahmadzadeh Kourosh, Bernaerts Eline, Martín-López Juan, Escriche Celia, Vanmechelen Bert, Krasniqi Besir, Singh Abhimanyu K, Daelemans Dirk, Maes Piet, Matthys Patrick, Dehaen Wim, Rozenski Jef, Das Kalyan, Voet Arnout, Vázquez Santiago, Naesens Lieve, Stevaert Annelies

Abstract excerpt

The approval of COVID-19 vaccines and antiviral drugs has been crucial to end the global health crisis caused by SARS-CoV-2. However, to prepare for future outbreaks from drug-resistant variants and novel zoonotic coronaviruses (CoVs), additional therapeutics with a distinct antiviral mechanism are needed. Here, we report a novel guanidine-substituted diphenylurea compound that suppresses CoV replication by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19 Drug Treatment

Share to Endoribonucleases

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39932973
DOI: 10.1371/journal.ppat.1012571
PMCID: PMC11856660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses.PMID 39932973Read ↗

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant virusesSemantic proximity Read ↗

Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonucleaseSemantic proximity Read ↗

The coronavirus nsp15 endoribonuclease: A puzzling protein and pertinent antiviral drug targetSemantic proximity Read ↗

The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved DrugsSemantic proximity Read ↗

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic targetSemantic proximity Read ↗

Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathwaysSemantic proximity Read ↗

SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responsesSemantic proximity Read ↗

SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cellsSemantic proximity Read ↗

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsSemantic proximity Read ↗

Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome CoronavirusSemantic proximity Read ↗

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signalingSemantic proximity Read ↗

Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico ScreeningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.