Article

Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonuclease

2020-12-10

Abstract excerpt

<h4>ABSTRACT</h4> The lack of medication to suppress coronavirus infections is a main reason for the dramatic course of the COVID-19 pandemic. There is an urgent need to identify suitable coronavirus drug targets and corresponding lead molecules. Here we describe the discovery of a class of coronavirus inhibitors acting on nsp15, a hexameric protein component of the viral replication-transcription complexes, endo...

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Literature Corpus work: 056f1347-a426-54b1-bf52-e459a3904104
DOI: 10.1101/2020.12.10.418996

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