Article
WNT11 suppresses tumor initiation and invasion by inactivating RAC1
2026-07-15
Abstract excerpt
<h4>ABSTRACT</h4> WNT11, a non-canonical WNT ligand, plays well-defined roles in development and tissue architecture; however, its function in cancer remains ambiguous. Here, we characterize WNT11 as a context-dependent suppressor of cancer stemness, invasion, and in vivo tumor formation in human epithelial cancer models. We show that WNT11 upregulation reduces the expression of stemness-promoting genes, suppres...
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Identifiers and source
- Literature Corpus work
- f8f18e13-fa53-52f2-9d71-04b80ca4c49d
- DOI
- 10.64898/2026.07.13.738348