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Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum

2025-04-18

Abstract excerpt

Epithelial cancers such as stomach and ovary cancer tend to metastasize to the peritoneum, often leading to intractable disease and poor survival. Currently, the mechanisms that enable gastric cancer cells to penetrate the mesothelium, and to implant, invade, and survive in the peritoneal niche are poorly understood. To investigate these mechanisms, we developed a novel human peritoneal explant model. Briefly, fre...

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Literature Corpus work
f8eebbfa-2f32-5557-a93e-f0808c01a6d2
DOI
10.1101/2025.04.14.648628
Open publication

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Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneumDOI 10.1101/2025.04.14.648628
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