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Spatial profiling identifies a GLIS2-associated fibroblast state linked to peritoneal recurrence in gastric cancer

2026-05-22

Abstract excerpt

<h4>Summary</h4> Cancer-associated fibroblasts are transcriptionally heterogeneous, yet how their reprogramming shapes gastric cancer progression remains unclear. Integrating single-cell and spatial transcriptomics, patient-derived fibroblast co-culture, and clinical cohorts, we identified a spatially organized continuum of extracellular matrix-producing fibroblasts. An inferred trajectory connected homeostatic E...

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Literature Corpus work
c7871f64-fdcd-5219-b864-e59a4caf4e1e
DOI
10.64898/2026.05.21.726806
Open publication

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Spatial profiling identifies a GLIS2-associated fibroblast state linked to peritoneal recurrence in gastric cancerDOI 10.64898/2026.05.21.726806
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