Article

Metalloprotease-driven remodeling of PTK7 and the cell surfaceome promotes metastatic fitness of circulating colorectal tumor cells

2026-07-27

Abstract excerpt

Circulating tumor cells (CTCs) are the potential seeds of distant metastases; however, little is known about how they survive in the bloodstream. Using a large cohort of colorectal cancer (CRC) patients, we found that the pseudokinase receptor PTK7 is highly expressed in primary tumors and metastatic lesions. Consistent with previous reports, high PTK7 expression is associated with reduced disease-free survival an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d2359f5-6c81-5bd8-a4ae-4675853db24b
DOI: 10.64898/2026.07.24.740526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metalloprotease-driven remodeling of PTK7 and the cell surfaceome promotes metastatic fitness of circulating colorectal tumor cellsDOI 10.64898/2026.07.24.740526Read

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells.Semantic proximity Read

Framing cancer progression: influence of the organ‐ and tumour‐specific matrisomeSemantic proximity Read

Single-cell transcriptomic analysis reveals dynamic changes in the liver microenvironment during colorectal cancer metastatic progressionSemantic proximity Read

MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavageSemantic proximity Read

Navigating ECM Barriers at the Invasive Front: The Cancer Cell–Stroma InterfaceSemantic proximity Read

Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progressionSemantic proximity Read

Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventionsSemantic proximity Read

PALMD supports spheroid integrity and anoikis resistance in ovarian cancer cellsSemantic proximity Read

The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.Semantic proximity Read

Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneumSemantic proximity Read

Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancerSemantic proximity Read

A Paracrine-to-Autocrine Shunt of GREM1 Fuels Colorectal Cancer Metastasis via ACVR1CSemantic proximity Read