Article

Pathway level subtyping identifies a slow-cycling and transcriptionally lethargic biological phenotype associated with poor clinical outcomes in colon cancer independent of genetics

2024-01-23

Abstract excerpt

Molecular stratification, across many tumour types, has used gene-level transcriptional data to identify subtypes associated with distinct genotypes and biological traits, as exemplified by the consensus molecular subtypes (CMS), and more recently the intrinsic CMS (iCMS), in colorectal cancer. In an attempt to develop molecular subtypes that more closely align to cancer-relevant phenotypic traits in KRAS mutant t...

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Literature Corpus work: f8de3632-df5e-5dd3-8fb3-b33764b5ad47
DOI: 10.21203/rs.3.rs-3891488/v1

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