Article
Phenotypic subtypes predict outcomes in colorectal cancer.
Acta oncologica (Stockholm, Sweden) - 1 Mar 2023
Kasurinen Jussi, Beilmann-Lehtonen Ines, Kaprio Tuomas, Hagström Jaana, Haglund Caj, Böckelman Camilla
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally. The Colorectal Cancer Subtyping Consortium used the transcriptome-based method to classify CRC according to four molecular subtypes, each showing different genomic alterations and prognoses: CMS1 (microsatellite instable [MSI] immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal). To expedite the...
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