Article
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Nature genetics - 1 Mar 2024
Malla Sudhir B, Byrne Ryan M, Lafarge Maxime W, Corry Shania M, Fisher Natalie C, Tsantoulis Petros K, Mills Megan L, Ridgway Rachel A, Lannagan Tamsin R M, Najumudeen Arafath K, Gilroy Kathryn L, Amirkhah Raheleh, Maguire Sarah L, Mulholland Eoghan J, Belnoue-Davis Hayley L, Grassi Elena, Viviani Marco, Rogan Emily, Redmond Keara L, Sakhnevych Svetlana, McCooey Aoife J, Bull Courtney, Hoey Emily, Sinevici Nicoleta, Hall Holly, Ahmaderaghi Baharak, Domingo Enric, Blake Andrew, Richman Susan D, Isella Claudio, Miller Crispin, Bertotti Andrea, Trusolino Livio, Loughrey Maurice B, Kerr Emma M, Tejpar Sabine, Maughan Timothy S, Lawler Mark, Campbell Andrew D, Leedham Simon J, Koelzer Viktor H, Sansom Owen J, Dunne Philip D
Abstract excerpt
Molecular stratification using gene-level transcriptional data has identified subtypes with distinctive genotypic and phenotypic traits, as exemplified by the consensus molecular subtypes (CMS) in colorectal cancer (CRC). Here, rather than gene-level data, we make use of gene ontology and biological activation state information for initial molecular class discovery. In doing so, we defined three pathway-derived...
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