Article

Positive selection of ORF3a and ORF8 genes drives the evolution of SARS-CoV-2 during the 2020 COVID-19 pandemic

2020-04-11

Abstract excerpt

In this study, we analyzed full-length SARS-CoV-2 genomes from multiple countries to determine early trends in the evolutionary dynamics of the novel COVID-19 pandemic. Results indicated SARS-CoV-2 evolved early into at least three phylogenetic groups, characterized by positive selection at specific residues of the accessory proteins OFR3a and ORF8a. We also report evidence of epistatic interactions among sites in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80b22bd9-fff7-5c13-abc9-67d5d2e42c6c
DOI: 10.1101/2020.04.10.035964

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Positive selection of ORF3a and ORF8 genes drives the evolution of SARS-CoV-2 during the 2020 COVID-19 pandemicDOI 10.1101/2020.04.10.035964Read

Positive Selection of ORF1ab, ORF3a, and ORF8 Genes Drives the Early Evolutionary Trends of SARS-CoV-2 During the 2020 COVID-19 PandemicSemantic proximity Read

Ongoing Positive Selection Drives the Evolution of SARS-CoV-2 GenomesSemantic proximity Read

Ongoing natural selection drives the evolution of SARS-CoV-2 genomesSemantic proximity Read

Subsequent Waves of Convergent Evolution in SARS-CoV-2 Genes and ProteinsSemantic proximity Read

SARS-CoV-2 genome evolution exposes early human adaptationsSemantic proximity Read

Ongoing global and regional adaptive evolution of SARS-CoV-2.Semantic proximity Read

Positive selection as a key player for SARS-CoV-2 pathogenicity: Insights into ORF1ab, S and E genesSemantic proximity Read

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.Semantic proximity Read

Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.Semantic proximity Read

Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations.Semantic proximity Read

Evolution of the SARS‐CoV ‐2 proteome in three dimensions (3D) during the first 6 months of the COVID ‐19 pandemicSemantic proximity Read

Genomic Analysis of SARS-CoV-2 Alpha, Beta and Delta Variants of Concern Uncovers Signatures of Neutral and Non-Neutral Evolution.Semantic proximity Read