Article

Structured Pooling Improves Detection of Rare Regulatory Mutations in Population-Scale Reporter Assays

2026-03-31

Abstract excerpt

Identifying genetic variants in noncoding DNA that impact gene expression and thereby contribute to disease risk remains a difficult but important challenge in genomic medicine. Modern reporter assays such as STARR-seq and MPRA provide an efficient and effective means of testing, in very high throughput, millions of variants captured directly from patient genomes. While these assays have previously been scaled to...

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Literature Corpus work: f8995192-eec2-5033-b2da-82db2243486a
DOI: 10.64898/2026.03.27.714794

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