Article
Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.
Genome research - 1 Aug 2015
Vockley Christopher M, Guo Cong, Majoros William H, Nodzenski Michael, Scholtens Denise M, Hayes M Geoffrey, Lowe William L, Reddy Timothy E
Abstract excerpt
We report a novel high-throughput method to empirically quantify individual-specific regulatory element activity at the population scale. The approach combines targeted DNA capture with a high-throughput reporter gene expression assay. As demonstration, we measured the activity of more than 100 putative regulatory elements from 95 individuals in a single experiment. In agreement with previous reports, we found...
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