Article

Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors

2022-09-14

Abstract excerpt

<title>Abstract</title> <p>Aim To synthesize novel uracil derivatives targeting thymidylate synthase for the treatment of high-grade malignancies such as breast cancer. Background Cell division is driven by nucleic acid metabolism, and thymidylate synthase (TYMS) catalyses a rate-limiting step in nucleotide synthesis. As a result, TYMS has emerged as a critical target in chemotherapy. 5-fluorouracil (5-FU) is c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f86a055b-1a96-5f96-be65-a872be629fd1
DOI: 10.21203/rs.3.rs-2053542/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase InhibitorsDOI 10.21203/rs.3.rs-2053542/v1Read

Novel opportunities for thymidylate metabolism as a therapeutic targetSemantic proximity Read

Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal CancerSemantic proximity Read

Unveiling the oncogenic significance of thymidylate synthase in human cancersSemantic proximity Read

Thymidylate Synthase Structure, Function and Implication in Drug DiscoverySemantic proximity Read

Unveiling the oncogenic significance of thymidylate synthase in human cancersSemantic proximity Read

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancersSemantic proximity Read

<i>In Vivo</i> Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial CompoundSemantic proximity Read

Computational Identification of Druggable Bioactive Compounds from Catharanthus roseus and Avicennia marina against Colorectal Cancer by Targeting Thymidylate SynthaseSemantic proximity Read

MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cellsSemantic proximity Read

Thymidylate Kinase: An Old Topic Brings New PerspectivesSemantic proximity Read

Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance roleSemantic proximity Read

miR-192/miR-215 Influence 5-Fluorouracil Resistance through Cell Cycle-Mediated Mechanisms Complementary to Its Post-transcriptional Thymidilate Synthase RegulationSemantic proximity Read