<i>In Vivo</i> Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

Abstract excerpt

There is an urgent need for new antibacterials that pinpoint novel targets and thereby avoid existing resistance mechanisms. We have created novel synthetic antibacterials through structure-based drug design that specifically target bacterial thymidylate kinase (TMK), a nucleotide kinase essential in the DNA synthesis pathway. A high-resolution structure shows compound TK-666 binding partly in the thymidine...

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