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Article

Novel opportunities for thymidylate metabolism as a therapeutic target

1 Sept 2008

Abstract excerpt

For over 40 years, the fluoropyrimidine 5-fluorouracil (5-FU) has remained the central agent in therapeutic regimens employed in the treatment of colorectal cancer and is frequently combined with the DNA-damaging agents oxaliplatin and irinotecan, increasing response rates and improving overall survival. However, many patients will derive little or no benefit from treatment, highlighting the need to identify...

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PMID: 18790783
DOI: 10.1158/1535-7163.mct-08-0280

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