Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.

Molecular biology of the cell - 15 Feb 2015

Cartwright Bethany R, Binns Derk D, Hilton Christopher L, Han Sungwon, Gao Qiang, Goodman Joel M

Abstract excerpt

Seipin is necessary for both adipogenesis and lipid droplet (LD) organization in nonadipose tissues; however, its molecular function is incompletely understood. Phenotypes in the seipin-null mutant of Saccharomyces cerevisiae include aberrant droplet morphology (endoplasmic reticulum-droplet clusters and size heterogeneity) and sensitivity of droplet size to changes in phospholipid synthesis. It has not been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to GTP-Binding Protein gamma Subunits

Share to Lipid Droplets

Share to Lipid Metabolism

Share to Phenotype

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 25540432
DOI: 10.1091/mbc.E14-08-1303
PMCID: PMC4325842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.PMID 25540432Read ↗

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology.Semantic proximity Read ↗

Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane.Semantic proximity Read ↗

Concept of lipid droplet biogenesisSemantic proximity Read ↗

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum.Semantic proximity Read ↗

Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even largerSemantic proximity Read ↗

Regulated conformational transitions in seipin define a functional ER–lipid droplet interfaceSemantic proximity Read ↗

Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation.Semantic proximity Read ↗

A role for phosphatidic acid in the formation of "supersized" lipid droplets.Semantic proximity Read ↗

“Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity”Semantic proximity Read ↗

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.Semantic proximity Read ↗

Seipin Deficiency as a Model of Severe Adipocyte Dysfunction: Lessons from Rodent Models and Teaching for Human Disease.Semantic proximity Read ↗

Seipin: from human disease to molecular mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.