Article
Drastic changes in the peptidoglycan composition of penicillin resistant laboratory mutants of Streptococcus pneumoniae.
FEMS microbiology letters - 15 Jul 1995
Severin A, Vaz Pato M V, Sá Figueiredo A M, Tomasz A
Abstract excerpt
The penicillin MIC of 2 Streptococcus pneumoniae clinical isolates was increased 100-fold (from 0.02 to 2.0 micromilligrams) and 20-fold (from 0.5 to 10.0 micromilligrams) through gradual exposure of the bacteria to increasing concentrations of penicillin in the laboratory. In both mutants the af...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Carrier Proteins
- Cell Wall
- Hexosyltransferases
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Molecular Weight
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Penicillin Resistance
- Penicillin-Binding Proteins
- Penicillins
- Peptidoglycan
- Peptidyl Transferases
- Streptococcus pneumoniae