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Article

Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae.

Molecular microbiology - 1 Sept 2006

Crisóstomo M Inês, Vollmer Waldemar, Kharat Arun S, Inhülsen Silja, Gehre Florian, Buckenmaier Stephan, Tomasz Alexander

Abstract excerpt

The level of penicillin resistance in clinical isolates of Streptococcus pneumoniae depends not only on the reduced affinity of penicillin binding proteins (PBPs) but also on the functioning of enzymes that modify the stem peptide structure of cell wall precursors. We used mariner mutagenesis in search of additional genetic determinants that may further attenuate the level of penicillin resistance in the...

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PMID: 16968223
DOI: 10.1111/j.1365-2958.2006.05340.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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