Article

The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of Adeno-Associated Virus Type 2 (wtAAV2) to cellular sites of DNA damage

2026-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Wild-type adeno-associated virus type 2 (wtAAV2) is a small, non-pathogenic DNA virus within the family Parvoviridae that is modified to engineer recombinant AAV (rAAV) vectors used in gene therapy. wtAAV2 genomes localize to nuclear domains enriched in DNA Damage Response (DDR) factors through mechanisms that remain unknown. We have discovered that the host transcription factor KLF4 (Krüppel-l...

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Literature Corpus work: f8399b3f-f333-5fa2-b81a-b79c2b6b6ef1
DOI: 10.64898/2026.02.24.707757

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