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Human CNS-3D organoids predict clinical seizure liability from calcium network activity

2026-05-23

Abstract excerpt

Drug-induced seizures remain a major safety concern in drug development, yet human seizure liability is difficult to predict using conventional preclinical models. Here, we evaluated whether spontaneous calcium network activity in human induced pluripotent stem cell-derived CNS-3D Brain Organoids could predict clinically observed seizure risk across a pharmacokinetically anchored drug set. CNS-3D organoids contain...

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Literature Corpus work
f82bfe0f-24a1-5ccb-a13e-913848d66ab7
DOI
10.64898/2026.05.20.726675
Open publication

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Human CNS-3D organoids predict clinical seizure liability from calcium network activityDOI 10.64898/2026.05.20.726675
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