Article
Permanganate oxidation reactions of DNA: perspective in biological studies.
Nucleosides, nucleotides & nucleic acids - 1 Sept 2003
Bui Chinh T, Rees Kylee, Cotton Richard G H
Abstract excerpt
KMnO4 has been well known as a powerful chemical probe for numerous applications in biological fields, particularly for those used in conformational studies of DNA. The KMnO4 assay provides essential information for understanding biochemical processes and detecting aberrant DNA, which is associated with many genetic diseases. Elegant examples are sequencing techniques, foot-printing assays for transcriptional...
Topics
- Base Composition
- DNA
- DNA Damage
- Gas Chromatography-Mass Spectrometry
- Mutation
- Nucleic Acid Conformation
- Nucleotides
- Oxidation-Reduction
- Potassium Permanganate