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Macrophage SLC9A1 Links Endocytic Trafficking to Innate Immune Activation in Myocardial Injury

2026-03-02

Abstract excerpt

Excessive innate immune activation drives adverse remodeling after myocardial infarction (MI), yet the upstream mechanisms by which macrophages sense ischemic danger signals remain poorly defined. Here we tested whether macropinocytosis functions as a mediator of post-ischemic inflammation and whether the Na⁺/H⁺ exchanger SLC9A1 links membrane ion transport to innate immune activation in the injured heart. Macropi...

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Identifiers and source

Literature Corpus work
f7f639ae-a48c-5376-ad50-6ad20620e1ba
DOI
10.64898/2026.02.27.708643
Open publication

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Macrophage SLC9A1 Links Endocytic Trafficking to Innate Immune Activation in Myocardial InjuryDOI 10.64898/2026.02.27.708643
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