Article

Spleen-derived Small Extracellular Vesicles Protect against Myocardial Infarction via Mediating Spleen-heart Crosstalk

2025-06-20

Abstract excerpt

<h4>Background and Aims</h4> Acute myocardial infarction (AMI) triggers systemic responses that influence cardiac injury and repair, but protective mediators within the cardiosplenic axis remain incompletely understood. This study aimed to investigate whether spleen-derived small extracellular vesicles (sEVs) exert cardioprotection after AMI, identify critical cargo, and evaluate their clinical relevance. <h4>Met...

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Literature Corpus work: 42a5f5ae-cf41-5cf4-ac7d-18f7e538fb75
DOI: 10.1101/2025.06.16.660039

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