Article

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay

2025-07-27

Abstract excerpt

Ubiquitin E3 ligases play crucial roles in the DNA damage response (DDR) by modulating the turnover, localization, activation, and interactions of DDR and DNA replication proteins. To gain further insight into how the ubiquitin system regulates the DDR, we performed a CRISPR-Cas9 knockout screen focused on E3 ligases and related proteins with the DNA topoisomerase I inhibitor, camptothecin. This uncovered the CTLH...

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Identifiers and source

Literature Corpus work: f7ddcf5d-6484-5fe5-aac7-2d730ca58513
DOI: 10.1101/2025.07.23.666279

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