Article

Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy

2024-03-22

Abstract excerpt

<title>Abstract</title> <p>Given the safety, tumor tropism, and ease of genetic manipulation in non-pathogenic <italic>Escherichia coli</italic> (<italic>E. coli</italic>), we designed a novel approach to deliver biologics to overcome poor trafficking and exhaustion of immune cells in the tumor microenvironment, via the surface display of key immune-activating cytokines on the outer membrane of <italic>E. coli</i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfc51e90-0b20-5c9e-a231-997e8c1af3f8
DOI: 10.21203/rs.3.rs-4031911/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapyDOI 10.21203/rs.3.rs-4031911/v1Read

Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responsesSemantic proximity Read

In Situ Synthesis of an Immune-Checkpoint Blocker from Engineered Bacteria Elicits a Potent Antitumor ResponseSemantic proximity Read

Microbial Systems Enhancing CAR-Based Therapies: A Synthetic Biology Paradigm for Next-Generation Cancer ImmunotherapySemantic proximity Read

Engineered Salmonella expressing IL-18 as a therapeutic strategy for colorectal cancerSemantic proximity Read

Unlocking The Potential and Myth of Personalized Vaccines, CRISPR-CAS9, and Bacteriotherapy, as Therapeutic Options for CancerSemantic proximity Read

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodiesSemantic proximity Read

An in situ immunogenicity-amplifying payload delivery system for immunotherapy of Kirsten rat sarcoma viral oncogene homolog-mutant cancer.Semantic proximity Read

Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responsesSemantic proximity Read

Programmable bacteria induce durable tumor regression and systemic antitumor immunitySemantic proximity Read

Repolarizing Neutrophils via MnO2 Nanoparticle-Activated STING Pathway Enhances Salmonella-Mediated Tumor ImmunotherapySemantic proximity Read

<i>Enterococcus</i> peptidoglycan remodeling promotes immune checkpoint inhibitor therapySemantic proximity Read

Tumor-targeting bacteria as immune stimulants – the future of cancer immunotherapy?Semantic proximity Read