Article

TDP-43 is required to build and maintain sarcomeres

2026-06-16

Abstract excerpt

<h4>Summary</h4> Skeletal muscle contractile units or sarcomeres require constant maintenance as they are subjected to continuous chemical and mechanical stress. When sarcomere maintenance is disrupted, as occurs in progressive neuromuscular diseases, muscle progressively atrophies, reducing muscle strength and motor control. Transient cytoplasmic ribonucleoprotein aggregates comprised of TDP-43 bound to mRNAs en...

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Literature Corpus work: 37a429f2-4dd9-5755-a51f-2e6f3e3cf71c
DOI: 10.64898/2026.06.16.732601

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