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Article

Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-Associated Macrophages and Their Precursor Cells in Tumor Progression.

Journal of proteome research - 2 Feb 2024

Liu Ying, Liu Di, Liu Yuchen, Fu Bin, Ji Shuhui, Wang Ruixuan, Yan Fang, Wang Huan, Zhao Dianyuan, Yang Wenting, Wang Jian, Tang Li

Abstract excerpt

Tumor-associated macrophages (TAMs) are key regulators in tumor progression, but the precise role of bone marrow-derived monocytes (Mons) as TAM precursors and their dynamic phenotypes regulated by the tumor microenvironment (TME) remain unclear. Here, we developed an optimized microproteomics workflow to analyze low-cell-number mouse myeloid cells. We sorted TAMs and their corresponding Mons (1 × 105 per sample)...

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Identifiers

PMID: 38173118
DOI: 10.1021/acs.jproteome.3c00725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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