Article

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

2018-09-03

Abstract excerpt

<h4>ABSTRACT</h4> The vast majority of malaria mortality is attributed to one parasite species: Plasmodium falciparum . Asexual replication of the parasite within the red blood cell is responsible for the pathology of the disease. In Plasmodium , the endoplasmic reticulum (ER) is a central hub for protein folding and trafficking as well as stress response pathways. In this study, we tested the role of an unchar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6015996-a044-5f3d-a07b-724569795beb
DOI: 10.1101/406181

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasitesDOI 10.1101/406181Read

A druggable oxidative folding pathway in the endoplasmic reticulum of human malaria parasitesSemantic proximity Read

The exported chaperone PfHsp70x is dispensable for the <i>Plasmodium falciparum</i> intraerythrocytic lifecycleSemantic proximity Read

A Plasmodium homolog of ER tubule‐forming proteins is required for parasite virulenceSemantic proximity Read

Essential role for HSP40 in asexual replication and thermotolerance of malaria parasitesSemantic proximity Read

The heat shock protein 40 family of the malaria parasite <i>Plasmodium falciparum</i>Semantic proximity Read

An endoplasmic reticulum resident molecular chaperone, GRP170, prevents stress-induced glomerular injurySemantic proximity Read

<i>Plasmodium falciparum</i> diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesionSemantic proximity Read

Characterisation of Two <i>Plasmodium</i> Virulence Factors Important for Lipid Metabolism and Disease Progression <i>In Vivo</i>Semantic proximity Read

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.Semantic proximity Read

Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patientsSemantic proximity Read

Plasmodium falciparum Molecular Chaperones: Guardians of the Malaria Parasite Proteome and Renovators of the Host ProteomeSemantic proximity Read

Essential role of a Plasmodium berghei heat shock protein (PBANKA_0938300) in gametocyte developmentSemantic proximity Read