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Article

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

10 Jun 2020

Abstract excerpt

, based on conditional expression of the PfAP2-G transcription factor. Using this system, ~90 percent of the parasites converted into sexual forms upon induction, enabling the characterization of committed and early sexual stages without further purification. We characterized sexually committed schizonts and sexual rings at the transcriptomic and phenotypic levels, which revealed down-regulation of genes involved...

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PMID: 32577509
DOI: 10.1126/sciadv.aaz5057

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