Article

Widespread haploid-biased gene expression in mammalian spermatogenesis associated with frequent selective sweeps and evolutionary conflict

2019-11-18

Abstract excerpt

1 Mendel’s first law dictates that alleles segregate randomly during meiosis and are distributed to offspring with equal frequency, requiring sperm to be functionally independent of their genetic payload. Developing mammalian spermatids have been thought to accomplish this by freely sharing RNA from virtually all genes through cytoplasmic bridges, equalizing allelic gene expression across different genotypes. Appl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1843af3-729d-5127-bdf4-cfa185f3d17f
DOI: 10.1101/846253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Widespread haploid-biased gene expression in mammalian spermatogenesis associated with frequent selective sweeps and evolutionary conflictDOI 10.1101/846253Read

Widespread haploid-biased gene expression enables sperm-level natural selectionSemantic proximity Read

The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesisSemantic proximity Read

Widespread transcriptional scanning in the testis modulates gene evolution ratesSemantic proximity Read

Insights into variation in meiosis from 31,228 human sperm genomes.Semantic proximity Read

Sperm mosaicism: implications for genomic diversity and disease.Semantic proximity Read

Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesisSemantic proximity Read

A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel's first law across a large sample of human sperm.Semantic proximity Read

Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertilitySemantic proximity Read

X-linked palindromic gene families <i>4930567H17Rik</i> and <i>Mageb5</i> are dispensable for male mouse fertilitySemantic proximity Read

Strict adherence to Mendel’s First Law across a large sample of human sperm genomesSemantic proximity Read

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formationSemantic proximity Read

Evolutionary innovations in germline biology of placental mammals revealed by transcriptomics of first wave spermatogenesis in opossumSemantic proximity Read