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Artemisinin acts by inhibiting <i>Plasmodium falciparum</i> Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

2021-07-12

Abstract excerpt

Reduced sensitivity of the human malaria parasite, Plasmodium falciparum, to Artemisinin and its derivatives (ARTs) threatens the global efforts towards eliminating malaria. ARTs have been shown to cause ubiquitous cellular and genetic insults, which results in the activation of the unfolded protein response (UPR) pathways. The UPR restores protein homeostasis, which otherwise would be toxic to cellular survival....

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Literature Corpus work
f774d1ca-1d0b-5b25-ae87-b6a102111510
DOI
10.1101/2021.07.12.452004
Open publication

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