Article

Drug resistance-associated mutations in <i>Plasmodium</i> UBP-1 disrupt ubiquitin hydrolysis

2022-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Deubiquitinating enzymes function to cleave ubiquitin moieties from modified proteins, serving to maintain the pool of free ubiquitin in the cell while simultaneously impacting the fate and function of a target protein. Like all eukaryotes, Plasmodium parasites rely on the dynamic addition and removal of ubiquitin for their own growth and survival. While humans possess around 100 DUBs, Plasmod...

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Literature Corpus work: dcdc8408-8eb3-536a-ad48-d70365cff8ab
DOI: 10.1101/2022.09.15.508122

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