Article

Affinity tag free purification of SARS-Cov-2 N protein and its crystal structure in complex with ssDNA

2024-09-17

Abstract excerpt

The nucleocapsid (N) protein is one of the four structural proteins in SARS-CoV-2, playing key roles in viral assembly, immune evasion, and stability. One of its primary functions is to protect viral RNA by forming the nucleocapsid. However, the precise mechanisms of how the N protein interacts with viral RNA and assembles into a nucleocapsid remain unclear. Compared to other SARS-CoV-2 components, the N protein h...

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Literature Corpus work: f7451cad-ed23-5062-a9df-22d8f23a2e70
DOI: 10.1101/2024.09.16.613250

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