Article

Mechanism of LLPS of SARS-CoV-2 N protein

2022-12-21

Abstract excerpt

SARS-CoV-2 nucleocapsid (N) protein with low mutation rate is the only structural protein not only functioning to package viral genomic RNA, but also manipulating the host-cell machineries, thus representing a key target for drug development. Recent discovery of its liquid-liquid phase separation (LLPS) not only sheds light on previously-unknown mechanisms underlying the host-SARS-CoV-2 interaction and viral life...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40d3f653-140b-55be-b11b-a2eb85db5564
DOI: 10.1101/2022.12.21.521431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanism of LLPS of SARS-CoV-2 N proteinDOI 10.1101/2022.12.21.521431Read

Contributions of the N-terminal intrinsically disordered region of the SARS-CoV-2 nucleocapsid protein to RNA-induced phase separationSemantic proximity Read

Contributions of the N‐terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA‐induced phase separationSemantic proximity Read

Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular FlexibilitySemantic proximity Read

Formation and Function of Liquid-Like Viral Factories in Negative-Sense Single-Stranded RNA Virus InfectionsSemantic proximity Read

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2Semantic proximity Read

Structural basis of anti-SARS-CoV-2 activity of HCQ: specific binding to N protein to disrupt its interaction with nucleic acids and LLPSSemantic proximity Read

Structural basis for the participation of the SARS-CoV-2 nucleocapsid protein in the template switch mechanism and genomic RNA reorganizationSemantic proximity Read

Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complexSemantic proximity Read

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteinsSemantic proximity Read

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNASemantic proximity Read

The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region.Semantic proximity Read

Affinity tag free purification of SARS-Cov-2 N protein and its crystal structure in complex with ssDNASemantic proximity Read