HDAC inhibitors rescue MeCP2 ^T158M speckles in a high content screen

Abstract excerpt

Rett syndrome (OMIM 312750) is a rare neurodevelopmental disorder caused by de novo mutations in the Methyl-CpG Binding Protein 2 (MeCP2) gene located on the X-Chromosome, typically affecting girls. Currently, available therapy for Rett Syndrome is only symptomatic. Rett syndrome symptoms first appear between 6 to 18 months of age, characterized by microcephaly and lack of motor coordination being the most preval...

Topics

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• Acetylation
• Chromosomal Proteins, Non-Histone
• Chromosomes
• Methyl-CpG-Binding Protein 2
• Mice
• Mutation
• Rett Syndrome
• X Chromosome Inactivation

Identifiers and source

Literature Corpus work

f6f2b713-80c7-5fab-a410-4a912742ef91

DOI

10.1101/2023.11.02.565272