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Article

Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression.

Bioorganic & medicinal chemistry letters - 15 Sept 2011

Yu Dongbo, Sakurai Fuminori, Corey David R

Abstract excerpt

Rett Syndrome is an X-linked progressive neurological disorder caused by inactivation of one allele of the MECP2 gene. There are no curative treatments, and activation of wild-type MECP2 expression is one strategy for stabilizing or reversing the disease. We isolated fibroblast clones that express exclusively either the wild-type or a 32-bp-deletion mutant form of MECP2. We developed a sensitive assay for...

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Source

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Identifiers

PMID: 21840716
DOI: 10.1016/j.bmcl.2011.07.053
PMCID: PMC3159815

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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