Article

Dose-dependent nuclear delivery and transcriptional repression with a cell-penetrant MeCP2

2022-06-04

Abstract excerpt

Methyl-CpG-binding-protein 2 (MeCP2) is a nuclear protein expressed in all cell types, especially neurons 1 . Mutations in the MECP2 gene cause Rett syndrome (RTT), an incurable neurological disorder that disproportionately affects young girls 2 . Strategies to restore MeCP2 expression phenotypically reverse RTT-like symptoms in male and female MeCP2-deficient mice 3–5 , suggesting that direct nuclear delivery...

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Literature Corpus work: 656e1877-616f-5585-b9ef-bc26caf95a31
DOI: 10.1101/2022.06.03.494754

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