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Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry

18 Oct 2023

Abstract excerpt

Abstract Cryptococcus spp. are environmental fungi that first must adapt to the host environment before they can cause life-threatening meningitis in immunocompromised patients. Host CO 2 concentrations are 100-fold higher than the external environment and strains unable to grow at host CO 2 concentrations are not pathogenic. Using a genetic screening and transcriptional profiling approach, we report that the TOR...

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PMID: 37852972
DOI: 10.1038/s41467-023-42318-y

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