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Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA)

21 Sept 2017

Abstract excerpt

LAG3 receptor belongs to a family of immune-checkpoints expressed in T lymphocytes and other cells of the immune system. It plays an important role as a rheostat of the immune response. Focus on this receptor as a potential therapeutic target in cancer immunotherapy has been underscored after the success of other immune-checkpoint blockade strategies in clinical trials. LAG3 showcases the interest in the field of...

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PMID: 28934318
DOI: 10.1371/journal.pone.0185169

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