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Article

The Sentinel Within: Exploiting the Immune System for Cancer Biomarkers

18 Jun 2005

Abstract excerpt

The release of proteins from tumors triggers an immune response in cancer patients. These tumor antigens arise from several mechanisms including tumor-specific alterations in protein expression, mutation, folding, degradation, or intracellular localization. Responses to most tumor antigens are rarely observed in healthy individuals, making the response itself a biomarker that betrays the presence of underlying...

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PMID: 16083262
DOI: 10.1021/pr0500814

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