Article

Cryo-EM structures of engineered Shiga toxin-based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against Hemolytic Uremic Syndrome

2024-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Shiga toxin-producing Escherichia coli -associated hemolytic uremic syndrome (STEC-HUS) is a serious disease that causes renal failure predominantly in children. Despite its significant impact, there are currently no licensed vaccines or effective therapies available. The B subunits of Shiga toxins 1 and 2 (Stx1B and Stx2B) are suitable targets for developing neutralizing antibodies, but their...

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Literature Corpus work: f64662d8-3965-5a48-861c-14659bca75fa
DOI: 10.1101/2024.12.21.626268

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