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Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies

12 Jun 2014

Abstract excerpt

UNLABELLED: Alphaviruses are serious, sometimes lethal human pathogens that belong to the family Togaviridae. The structures of human Venezuelan equine encephalitis virus (VEEV), an alphavirus, in complex with two strongly neutralizing antibody Fab fragments (F5 and 3B4C-4) have been determined using a combination of cryo-electron microscopy and homology modeling. We characterize these monoclonal antibody Fab...

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PMID: 24920796
DOI: 10.1128/jvi.01286-14

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