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Article

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis

15 Nov 2015

Abstract excerpt

Parasitic helminth worms, such as Schistosoma mansoni, are endemic in regions with a high prevalence of tuberculosis (TB) among the population. Human studies suggest that helminth coinfections contribute to increased TB susceptibility and increased rates of TB reactivation. Prevailing models suggest that T helper type 2 (Th2) responses induced by helminth infection impair Th1 immune responses and thereby limit...

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PMID: 26571397
DOI: 10.1172/jci77378

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