Article

Enhanced CICR activity reduces ER Ca <sup>2+</sup> level in cells expressing CPVT-linked mutant RyR2

2021-01-18

Abstract excerpt

Type 2 ryanodine receptor (RyR2) is a cardiac Ca 2+ release channel in the endoplasmic reticulum (ER). Mutations in RyR2 are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), which is considered to be associated with enhanced spontaneous Ca 2+ release. This spontaneous Ca 2+ release tends to occur when ER Ca 2+ ([Ca 2+ ] ER ) reaches a certain threshold level, and CPVT mutations are rep...

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Literature Corpus work: f635eed8-18d1-52d3-94a2-9c2f42ea6af7
DOI: 10.1101/2021.01.16.426980

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