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Article

A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium.

Circulation research - 22 Jul 2011

Meli Albano C, Refaat Marwan M, Dura Miroslav, Reiken Steven, Wronska Anetta, Wojciak Julianne, Carroll Joan, Scheinman Melvin M, Marks Andrew R

Abstract excerpt

RATIONALE: Mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT-associated RyR2 mutations cause fatal ventricular arrhythmias in young individuals during β-adrenergic stimulation. OBJECTIVE: This study sought to determine the effects of a novel RyR2-G230C mutation and whether this mutation and RyR2-P2328S alter the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ryanodine Receptor Calcium Release Channel

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Source

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Identifiers

PMID: 21659649
DOI: 10.1161/CIRCRESAHA.111.244970
PMCID: PMC3690513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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