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Article

Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2.

The Journal of general physiology - 5 Sept 2022

Kurebayashi Nagomi, Murayama Takashi, Ota Ryosaku, Suzuki Junji, Kanemaru Kazunori, Kobayashi Takuya, Ohno Seiko, Horie Minoru, Iino Masamitsu, Yamashita Fumiyoshi, Sakurai Takashi

Abstract excerpt

Type 2 ryanodine receptor (RYR2) is a cardiac Ca2+ release channel in the ER. Mutations in RYR2 are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT is associated with enhanced spontaneous Ca2+ release, which tends to occur when [Ca2+]ER reaches a threshold. Mutations lower the threshold [Ca2+]ER by increasing luminal Ca2+ sensitivity or enhancing cytosolic [Ca2+] ([Ca2+]cyt)-dependent...

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Identifiers

PMID: 35446340
DOI: 10.1085/jgp.202112869
PMCID: PMC9037340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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