Article
Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes.
Molecular biology of the cell - 1 Dec 2013
Thapa Mamata, Bommakanti Ananth, Shamsuzzaman Md, Gregory Brian, Samsel Leigh, Zengel Janice M, Lindahl Lasse
Abstract excerpt
The biogenesis of ribosomes is coordinated with cell growth and proliferation. Distortion of the coordinated synthesis of ribosomal components affects not only ribosome formation, but also cell fate. However, the connection between ribosome biogenesis and cell fate is not well understood. To establish a model system for inquiries into these processes, we systematically analyzed cell cycle progression, cell...
Topics
- Cell Cycle
- Cell Nucleus
- DNA, Fungal
- Flow Cytometry
- Models, Biological
- Phenotype
- Protein Biosynthesis
- Ribosomal Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins