Article

SchizoCircuit: An Auditable, Claim-Governed Nextflow Workflow for Synthetic GWAS-to-Gene Evidence Integration

2026-08-31

Abstract excerpt

BACKGROUND. Locus-to-gene prioritization can combine association statistics, fine mapping, molecular QTL evidence, regulatory annotation, and literature-derived context, but heterogeneous evidence layers are vulnerable to double counting, hidden thresholds, non-reproducible execution, and claims that exceed what the data support. We developed SchizoCircuit as a claim-governed, auditable workflow motivated by schiz...

Identifiers and source

Literature Corpus work: f63184a5-72e1-5756-973a-24cb9a9f80c6
DOI: 10.32388/05u7a8.2

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

SchizoCircuit: An Auditable, Claim-Governed Nextflow Workflow for Synthetic GWAS-to-Gene Evidence IntegrationDOI 10.32388/05u7a8.2Read

Prioritizing effector genes at trait-associated loci using multimodal evidence.Semantic proximity Read

BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data.Semantic proximity Read

Gene prioritization in GWAS loci using multimodal evidenceSemantic proximity Read

A Claim-Governed Framework for Conservative Molecular Candidate Prioritization in SchizophreniaSemantic proximity Read

BDQC: a general-purpose analytics tool for domain-blind validation of Big DataSemantic proximity Read

LocusPackRat: a Semi-Automated Framework for Prioritizing Candidate Genes from Large GWAS IntervalsSemantic proximity Read

Performing highly parallelized and reproducible GWAS analysis on biobank-scale dataSemantic proximity Read

Automated GenePy Gene-Burden Computation via a Reproducible Nextflow Workflow Integrated with the Genomics England (GEL) Lifebit PlatformSemantic proximity Read

When pipelines run but coordinates fail: A simple spatial specificity check for false locality in post-GWAS analysis.Semantic proximity Read

S2F-Agent: Harnessing sequence-to-function models for verifiable genome interpretationSemantic proximity Read

BioQ: tracing experimental origins in public genomic databases using a novel data provenance model.Semantic proximity Read

Enabling Precision Medicine via standard communication of HTS provenance, analysis, and resultsSemantic proximity Read