When pipelines run but coordinates fail: A simple spatial specificity check for false locality in post-GWAS analysis.

Abstract excerpt

Some post-GWAS analysis software can run to completion without reporting an error while producing results that are not biologically valid. We call this failure false locality: a result appears to be local to a gene or protein because it was produced from a regional window, but the window or its metadata points to the wrong genomic address. We identify three mechanisms. First, a genome-build address mismatch...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CXCL10 gene
• Share to Genome-Wide Association Study